Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder.
نویسندگان
چکیده
Ru(II)(arene)-flavonoids with high in vitro antitumour activity were synthesised. These compounds are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 40 شماره
صفحات -
تاریخ انتشار 2012